Sha'afi R I, Naccache P
J Cell Physiol. 1975 Jun;85(3):655-64. doi: 10.1002/jcp.1040850318.
The transport of radioactive sodium and calcium in high sodium low potassium cat red blood cells has been studied under various experimental conditions. In these cells, calcium uptake was found to increase by 25-fold when cell volume was decreased from 1.0 normal to 0.55. Increasing cell volume from 1.0 to 1.1 normal was found to decrease calcium-uptake by 30%. N-ethylmaleimide, NEM, phloretin, colchicine, and vinblastine were found to inhibit Na-uptake by these cells. Among these four agents, phloretin was the most potent inhibitor of Na-influx. It appears that phloretin produces its effect through its interaction with the cell membrane and not with cell interior.
在各种实验条件下，对高钠低钾猫红细胞中放射性钠和钙的转运进行了研究。在这些细胞中，当细胞体积从1.0正常水平降至0.55时，钙摄取量增加了25倍。发现将细胞体积从1.0增加到1.1正常水平会使钙摄取量减少30%。已发现N-乙基马来酰亚胺（NEM）、根皮素、秋水仙碱和长春碱会抑制这些细胞对钠的摄取。在这四种试剂中，根皮素是最有效的钠内流抑制剂。看来根皮素是通过与细胞膜相互作用而不是与细胞内部相互作用来产生其作用的。
