使用特定氮检测器常规测定血浆中三环类抗抑郁药的灵敏方法。
Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector.
作者信息
Gifford L A, Turner P, Pare C M
出版信息
J Chromatogr. 1975 Feb 19;105(1):107-13. doi: 10.1016/s0021-9673(01)81094-3.
PMID:1141399
Abstract
The sensitivity of the alkali flame ionization detector to the tricyclic antidepressant drugs has been studied and limits of detection measured. A backflush system has been used to enable measurement in plasma extracts. A general method for the estimation of tricyclic plasma levels has been developed and exemplified by the measurement of imipramine at therapeutic levels.
摘要
已对碱火焰离子化检测器对三环类抗抑郁药的灵敏度进行了研究，并测定了检测限。采用反吹系统以便能够对血浆提取物进行测定。已开发出一种估算三环类药物血浆水平的通用方法，并以治疗水平下丙咪嗪的测定为例进行了说明。
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