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急性过量用药时的抗抑郁药血药浓度。

Antidepressant blood levels in acute overdose.

作者信息

Hallstrom C, Gifford L

出版信息

Postgrad Med J. 1976 Nov;52(613):687-8. doi: 10.1136/pgmj.52.613.687.

DOI:10.1136/pgmj.52.613.687
PMID:1012995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2496349/
Abstract

Plasma antidepressant levels and clinical condition were measured sequentially for at least 24 hr in eight patients who presented with acute antidepressant overdosage. There was no evidence to suggest that a knowledge of the drug plasma levels had anything to offer in the management of a patient whose overdose included a tricyclic antidepressant.

摘要

对8例急性抗抑郁药过量的患者连续至少24小时测量其血浆抗抑郁药水平及临床状况。没有证据表明,对于过量服用药物中包括三环类抗抑郁药的患者,了解其血浆药物水平对治疗有任何帮助。

相似文献

1
Antidepressant blood levels in acute overdose.急性过量用药时的抗抑郁药血药浓度。
Postgrad Med J. 1976 Nov;52(613):687-8. doi: 10.1136/pgmj.52.613.687.
2
Tricyclic antidepressant overdose: clinical presentation and plasma levels.三环类抗抑郁药过量:临床表现与血药浓度
Clin Pharmacol Ther. 1975 Nov;18(5 Pt 1):539-46. doi: 10.1002/cpt1975185part1539.
3
Tricyclic antidepressants in red cells and plasma: correlation with impaired intraventricular conduction in acute overdose.红细胞和血浆中的三环类抗抑郁药:与急性过量时室内传导受损的相关性
Clin Pharmacol Ther. 1993 Aug;54(2):219-27. doi: 10.1038/clpt.1993.133.
4
Predicting severity of tricyclic antidepressant overdose.预测三环类抗抑郁药过量的严重程度。
J Toxicol Clin Toxicol. 1992;30(2):161-70. doi: 10.3109/15563659209038628.
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Recognition and management of antidepressant overdoses: tricyclics and trazodone.抗抑郁药过量的识别与处理:三环类药物和曲唑酮
Neuropsychobiology. 1986;15 Suppl 1:46-51. doi: 10.1159/000118287.
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Tricyclic antidepressants. Prolonged plasma levels after overdose.三环类抗抑郁药。过量服用后血浆水平延长。
JAMA. 1976 Oct 11;236(15):1711-2. doi: 10.1001/jama.236.15.1711.
7
Tricyclic antidepressant overdose: clinical features and management.三环类抗抑郁药过量:临床特征与处理
Heart Lung. 1983 May;12(3):222-5.
8
Tricyclic antidepressant overdose: incidence of symptoms.三环类抗抑郁药过量:症状发生率
JAMA. 1977 Jul 11;238(2):135-8.
9
Physostigmine in tricyclic antidepressant overdose.毒扁豆碱用于三环类抗抑郁药过量中毒
JACEP. 1976 Jun;5(6):443-5. doi: 10.1016/s0361-1124(76)80255-9.
10
Brugada syndrome mimicked by tricyclic antidepressant overdose.三环类抗抑郁药过量所致的酷似Brugada综合征的情况。
J Cardiovasc Electrophysiol. 2001 Feb;12(2):275. doi: 10.1046/j.1540-8167.2001.00275.x.

引用本文的文献

1
Severe dothiepin intoxication--a report of two cases.严重多虑平中毒——两例报告
Postgrad Med J. 1984 Jun;60(704):442-4. doi: 10.1136/pgmj.60.704.442.
2
Antidepressant overdosage.抗抑郁药过量服用。
Drugs. 1982 Jun;23(6):431-61. doi: 10.2165/00003495-198223060-00002.
3
Poisoning due to tricyclic antidepressant overdosage. Clinical presentation and treatment.三环类抗抑郁药过量中毒。临床表现与治疗。
Med Toxicol. 1986 Jul-Aug;1(4):261-85. doi: 10.1007/BF03259843.
4
Relationship between clinical features of tricyclic antidepressant poisoning and plasma concentrations in children.儿童三环类抗抑郁药中毒的临床特征与血浆浓度之间的关系。
Arch Dis Child. 1978 Nov;53(11):902-5. doi: 10.1136/adc.53.11.902.

本文引用的文献

1
Relationship between plasma level and therapeutic effect of nortriptyline.去甲替林血药浓度与治疗效果的关系。
Br Med J. 1971 Aug 7;3(5770):331-4. doi: 10.1136/bmj.3.5770.331.
2
Overdosage of tricyclic antidepressants. A report of two deaths and a prospective study of 24 patients.三环类抗抑郁药过量。两例死亡报告及对24例患者的前瞻性研究。
Med J Aust. 1972 Jul 8;2(2):74-9.
3
Plasma concentration of amitriptyline and clinical response.阿米替林的血浆浓度与临床反应。
Lancet. 1972 Jun 17;1(7764):1297-300. doi: 10.1016/s0140-6736(72)91031-8.
4
Sensitive method for the routine determination tricyclic antidepressants in plasma using a specific nitrogen detector.使用特定氮检测器常规测定血浆中三环类抗抑郁药的灵敏方法。
J Chromatogr. 1975 Feb 19;105(1):107-13. doi: 10.1016/s0021-9673(01)81094-3.