Treeprasertsuk S, Viriyavejakul P, Silachamroon U, Vannphan S, Wilairatana P, Looareesuwan S
Department of Tropical Medicine, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 2000 Dec;31(4):825-8.
We reported two cases of complicated falciparum malaria who had poor response to artesunate with delayed parasite clearance times. They were splenectomized patients who were treated with high doses of artemisinin derivatives. Our cases showed the importance of the spleen in the clearance of malaria parasites and had different clinical outcome, one fatal and one recovery. The host factors, the parasitemia count, the quality of antimalarial chemotherapy and blood level of the antimalarial drugs must be considered in relation to the causes of the delayed clearance of parasitemia.
我们报告了两例复杂型恶性疟病例，这两名患者对青蒿琥酯反应不佳，疟原虫清除时间延迟。他们是接受高剂量青蒿素衍生物治疗的脾切除患者。我们的病例显示了脾脏在清除疟原虫中的重要性，并且有不同的临床结局，一例死亡，一例康复。必须结合疟原虫血症清除延迟的原因来考虑宿主因素、疟原虫计数、抗疟化疗质量以及抗疟药物的血药浓度。
