Fisher L B, Maibach H I
J Invest Dermatol. 1975 May;64(5):338-41. doi: 10.1111/1523-1747.ep12512282.
An attempt was made to clarify the effect of anthralin on epidermal cell kinetics. Commercial anthralin powder was separated by column chromatography into three components: pure anthralin, 1,8-dihydroxyanthroquinotne, and anthralin dimer. The effect of these on the diurnal mitotic variation and the cell cycle of the hairless mouse epidermis was studied. Neither anthroquinone nor the anthralin dimer had any influence on these parameters. Both the chromatographically pure and commercial anthralins had similar effects. Mitotic activity was considerably reduced, although not to zero, with concomitant elimination of the diurnal peak. The G2 and S phases of the cell cycle were approximately doubled in length. Application of the pure and commercial anthralin also resulted in some irritation not seen with either the anthroquinone or dimer.
有人试图阐明蒽林对表皮细胞动力学的影响。商用蒽林粉末通过柱色谱法分离为三个组分：纯蒽林、1,8 - 二羟基蒽醌和蒽林二聚体。研究了它们对无毛小鼠表皮昼夜有丝分裂变化和细胞周期的影响。蒽醌和蒽林二聚体对这些参数均无任何影响。色谱纯蒽林和商用蒽林具有相似的效果。有丝分裂活性显著降低，虽未降至零，但昼夜峰值消失。细胞周期的G2期和S期长度大约增加了一倍。应用纯蒽林和商用蒽林还会导致一些蒽醌或二聚体未出现的刺激现象。
