蒽林（地蒽酚）对线粒体的作用。

The effect of anthralin (dithranol) on mitochondria.

作者信息

Morlière P, Dubertret L, Sa e Melo T, Salet C, Fosse M, Santus R

出版信息

Br J Dermatol. 1985 May;112(5):509-15. doi: 10.1111/j.1365-2133.1985.tb15258.x.

DOI:10.1111/j.1365-2133.1985.tb15258.x

Abstract

The short-term effect of topical application of anthralin (dithranol) on normal human skin was investigated by electron microscopy. Mitochondria appeared markedly damaged. By contrast other cellular structures, particularly the nuclear and cytoplasmic membranes were unchanged. In vitro experiments were therefore performed on isolated rat liver mitochondria and it was shown that anthralin acts as an uncoupler of oxidative phosphorylation. These results suggest that anthralin can inhibit the adenosine triphosphate supply in epidermal cells. This loss of energy supply in keratinocytes could explain, at least in part, the therapeutic efficiency of anthralin in psoriasis.

摘要

通过电子显微镜研究了外用蒽林（地蒽酚）对正常人皮肤的短期影响。线粒体出现明显损伤。相比之下，其他细胞结构，特别是核膜和细胞质膜未发生变化。因此，对分离的大鼠肝脏线粒体进行了体外实验，结果表明蒽林可作为氧化磷酸化的解偶联剂。这些结果表明，蒽林可抑制表皮细胞中三磷酸腺苷的供应。角质形成细胞能量供应的这种丧失至少可以部分解释蒽林治疗银屑病的疗效。