Gilman S E, Abraham H D
Department of Health and Social Behavior, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA.
Drug Alcohol Depend. 2001 Aug 1;63(3):277-86. doi: 10.1016/s0376-8716(00)00216-7.
Alcohol dependence and major depression commonly occur together; however, few studies have assessed prospectively the magnitude of the risk that one disorder imparts on the subsequent occurrence of the other. We used data from the first two waves of the Epidemiologic Catchment Area community survey (n=14480) to estimate the odds of either major depression or alcohol dependence being followed by the other disorder after 1 year of follow-up. The odds of developing major depression associated with low, medium, and high levels of alcoholic symptoms at baseline were 1.66, 3.98, and 4.32 for females (P<0.001), and 1.19, 2.49, and 2.12 for males (P=0.026). Conversely, odds ratios indicating the 1-year follow-up risk of incident alcohol dependence within low, medium, and high categories of baseline depressive symptomatology were 2.75, 3.52, and 7.88 for females (P<0.001) and 1.50, 1.41, and 1.05 for males (P=0.091). Individuals with alcohol dependence appeared more likely to meet lifetime diagnostic criteria for both disorders after 1 year than individuals with depression. These results suggest that both alcohol dependence and major depression pose a significant risk for the development of the other disorder at 1 year.
酒精依赖和重度抑郁症常常同时出现；然而，很少有研究前瞻性地评估一种疾病对另一种疾病后续发生风险的影响程度。我们使用了流行病学集水区社区调查前两波的数据（n = 14480）来估计在1年随访后，重度抑郁症或酒精依赖继之以另一种疾病的几率。在基线时，女性出现与低、中、高水平酒精症状相关的重度抑郁症的几率分别为1.66、3.98和4.32（P<0.001），男性分别为1.19、2.49和2.12（P = 0.026）。相反，在基线抑郁症状的低、中、高类别中，表明女性发生酒精依赖的1年随访风险的优势比分别为2.75、3.52和7.88（P<0.001），男性分别为1.50、1.41和1.05（P = 0.091）。与患有抑郁症的个体相比，患有酒精依赖的个体在1年后似乎更有可能符合两种疾病的终生诊断标准。这些结果表明，酒精依赖和重度抑郁症在1年时都会对另一种疾病的发生构成重大风险。
