Clinical Center, Translational Biobehavioral and Health Disparities Branch, National Institutes of Health, Bethesda, Maryland, USA
Clinical Center, Translational Biobehavioral and Health Disparities Branch, National Institutes of Health, Bethesda, Maryland, USA.
BMJ Open. 2024 Mar 21;14(3):e079823. doi: 10.1136/bmjopen-2023-079823.
Heavy alcohol use and alcohol use disorder (AUD) continues to rise as a public health problem and increases the risk for disease. Elevated rates of anxiety, depression, sleep disruption and stress are associated with alcohol use. Symptoms may progress to diagnosed neurophysiological conditions and increase risk for relapse if abstinence is attempted. Research on mechanisms connecting the gastrointestinal microbiome to neuropsychological disorders through the gut-brain axis is well-established. Less is known how the oral microbiome and oral microbial-associated biomarkers may signal to the brain. Therefore, a synthesis of research studying relationships between alcohol intake, alcohol-associated neurophysiological symptoms and the oral microbiome is needed to understand the state of the current science. In this paper, we outline our protocol to collect, evaluate and synthesise research focused on associations between alcohol intake and AUD-related neuropsychological disorders with the oral microbiome.
The search strategy was developed and will be executed in collaboration with a medical research librarian. Studies will be screened by two independent investigators according to the aim of the scoping review, along with the outlined exclusion and inclusion criteria. After screening, data will be extracted and synthesised from the included papers according to predefined demographic, clinical and microbiome methodology metrics.
A scoping review of primary sources is needed to synthesise the data on relationships between alcohol use, neuropsychological conditions associated with AUD and the oral microbiome. The proposed scoping review is based on the data from publicly available databases and does not require ethical approval. We expect the results of this synthesis will identify gaps in the growing literature and highlight potential mechanisms linking the oral-brain axis to addiction and other associated neuropsychological conditions. The study findings and results will be disseminated through journals and conferences related to psychology, neuroscience, dentistry and the microbiome.
作为一个公共卫生问题，大量饮酒和酒精使用障碍（AUD）持续上升，增加了患病风险。焦虑、抑郁、睡眠障碍和压力升高与酒精使用有关。如果试图戒酒，症状可能会发展为诊断性神经生理状况，并增加复发的风险。通过肠-脑轴将胃肠道微生物组与神经心理障碍联系起来的研究机制已经得到充分证实。但人们对口腔微生物组和口腔微生物相关生物标志物如何向大脑发出信号知之甚少。因此，需要综合研究酒精摄入、与酒精相关的神经生理症状和口腔微生物组之间的关系，以了解当前科学的状况。在本文中，我们概述了我们的方案，以收集、评估和综合研究酒精摄入与 AUD 相关神经心理障碍与口腔微生物组之间的关系。
搜索策略是与医学研究图书馆员合作制定和执行的。根据范围综述的目的以及概述的排除和纳入标准，将由两名独立的调查人员对研究进行筛选。筛选后，将根据预先确定的人口统计学、临床和微生物组方法学指标，从纳入的论文中提取和综合数据。
需要对原始资料进行范围综述，以综合酒精使用、与 AUD 相关的神经心理状况和口腔微生物组之间关系的数据。拟议的范围综述基于公开数据库中的数据，不需要伦理批准。我们预计这项综合研究的结果将确定不断增长的文献中的差距，并强调将口腔-大脑轴与成瘾和其他相关神经心理状况联系起来的潜在机制。该研究结果将通过与心理学、神经科学、牙科学和微生物组相关的期刊和会议进行传播。
