Conlin P A, Orden M B, Hough T R, Morgan D L
Department of Pathology, Texas Tech University Medical Center, Lubbock, TX 794430, USA.
Arch Pathol Lab Med. 2001 Jul;125(7):948-50. doi: 10.5858/2001-125-0948-MPILBC.
Intravascular large B-cell lymphoma (IVLBL) is an uncommon form of non-Hodgkin lymphoma that is also known as malignant angioendotheliosis, intravascular lymphomatosis, and angiotropic large-cell lymphoma. The disease is characterized by a bizarre population of neoplastic cells, which are found systemically within vascular lumina. Although originally thought to be a neoplastic process of the endothelial cells, it has since been demonstrated, by molecular techniques and immunohistochemistry, that the neoplastic cells are of lymphoid origin. The differential diagnosis of these lesions includes granulocytic sarcomas that can be distinguished from IVLBL or other lymphomas by the presence of immunohistochemical positivity for myeloperoxidase. We describe a patient with a history of a myelodysplastic syndrome who subsequently developed IVLBL, which demonstrated immunohistochemical positivity for myeloperoxidase. To our knowledge, this represents the first case of a malignant lymphoma to demonstrate such findings.
血管内大B细胞淋巴瘤（IVLBL）是一种罕见的非霍奇金淋巴瘤，也被称为恶性血管内皮瘤病、血管内淋巴瘤病和嗜血管大细胞淋巴瘤。该疾病的特征是一群形态怪异的肿瘤细胞，它们系统性地存在于血管腔内。尽管最初认为是内皮细胞的肿瘤性病变，但通过分子技术和免疫组织化学已证实，肿瘤细胞起源于淋巴组织。这些病变的鉴别诊断包括粒细胞肉瘤，其可通过髓过氧化物酶免疫组织化学阳性与IVLBL或其他淋巴瘤相区分。我们报告一例有骨髓增生异常综合征病史的患者，随后发生了IVLBL，该病例显示髓过氧化物酶免疫组织化学阳性。据我们所知，这是首例出现此类表现的恶性淋巴瘤病例。
