Jaalouk G, Avvisati G, Latagliata R, Pacchiarotti A, Pulsoni A, Mecarocci S, Malagnino F
Department of Human Biopathology, University La Sapienza, Rome, Italy.
Leuk Lymphoma. 1996 Apr;21(3-4):339-41. doi: 10.3109/10428199209067617.
We describe a case of simultaneous occurrence of large B-cell non-Hodgkin lymphoma and myelodysplastic syndrome in the absence of previous chemotherapy or radiotherapy. After initiation of steroid treatment, the myeloid clone showed a rapid increase in both the bone marrow and peripheral blood with transformation into acute myeloid leukemia. The diagnosis were confirmed by immunophenotypic studies performed in the histologic sections of the lymph node, as well as in bone marrow and peripheral blast cells. This case may be indicative of potential down-regulation of a malignant myeloid clone induced by the malignant lymphoid clone.
我们描述了一例在未接受过化疗或放疗的情况下同时发生大B细胞非霍奇金淋巴瘤和骨髓增生异常综合征的病例。在开始使用类固醇治疗后，髓系克隆在骨髓和外周血中均迅速增加，并转化为急性髓系白血病。通过在淋巴结、骨髓和外周原始细胞的组织学切片中进行的免疫表型研究证实了诊断。该病例可能表明恶性淋巴克隆诱导恶性髓系克隆发生潜在的下调。
