伴CD5和CD10共表达的低级别B细胞淋巴瘤。3例报告。

Low-grade B-cell lymphoma with coexpression of both CD5 and CD10. A report of 3 cases.

作者信息

Barekman C L, Aguilera N S, Abbondanzo S L

机构信息

Department of Pathology, Walter Reed Army Medical Center, Washington, DC 20307, USA

出版信息

Arch Pathol Lab Med. 2001 Jul;125(7):951-3. doi: 10.5858/2001-125-0951-LGBCLW.

DOI:10.5858/2001-125-0951-LGBCLW

PMID:11419985

Abstract

The coexpression of CD5 and CD10 has previously been reported in cases of intermediate- and high-grade lymphomas and in precursor B cells in normal or regenerating bone marrow. We report 3 cases of low-grade B-cell lymphoma that were found to coexpress CD5 and CD10 at the time of initial diagnosis. The first case was classified as small lymphocytic lymphoma; the second as follicle center lymphoma, follicular grade 1; and the third as small B-cell lymphoma otherwise not specified. Currently, the clinical implication of the coexpression of CD5 and CD10 is not known. We describe this finding to highlight the difficulty that may be encountered in classifying lymphomas in cases where this coexpression is present.

摘要

先前已有报道称，在中高级别淋巴瘤病例以及正常或再生骨髓中的前体B细胞中存在CD5和CD10的共表达。我们报告了3例在初诊时被发现同时表达CD5和CD10的低级别B细胞淋巴瘤病例。第一例被分类为小淋巴细胞淋巴瘤；第二例为滤泡中心淋巴瘤，1级滤泡；第三例为未另行指定的小B细胞淋巴瘤。目前，CD5和CD10共表达的临床意义尚不清楚。我们描述这一发现是为了强调在存在这种共表达的病例中对淋巴瘤进行分类时可能遇到的困难。