起源于CD5阳性滤泡性淋巴瘤的CD5阳性弥漫性大B细胞淋巴瘤。
CD5-positive diffuse large B cell lymphoma arising from a CD5-positive follicular lymphoma.
作者信息
Vassallo José, Bousquet Marina, Quelen Cathy, Al Saati Talal, Delsol Georges, Brousset Pierre
机构信息
Department of Anatomic Pathology, Faculty of Medical Sciences, State University of Campinas, São Paulo, Brazil.
出版信息
J Clin Pathol. 2007 May;60(5):573-5. doi: 10.1136/jcp.2005.032896.
Follicular lymphoma (FL) is a neoplasm originating from germinal centre cells, corresponding to 25-40% of non-Hodgkin's lymphomas. Transformation into diffuse large B cell lymphoma (DLBCL) occurs in about one-third of cases. CD5 is expressed in B-chronic lymphoid leukaemia/small lymphocytic lymphoma and mantle cell lymphoma, but can rarely be expressed in conjunction with CD10 in well-documented cases of FL. In this report one case of grade 1 FL is described, which transformed into a DLBCL 6 months after initial diagnosis, with both tumours expressing CD5. In both specimens, neoplastic cells were strongly positive for CD20, CD79a, bcl-2, bcl-6 and CD5 in virtually all cells. CD10 was strongly positive in initial specimens and weakly positive in the DLBCL. Investigation using the PCR confirmed the derivation of the DLBCL from the FL as they presented the same immunoglobulin heavy chain gene rearrangement and the same BCL2-J(H) break point.
滤泡性淋巴瘤（FL）是一种起源于生发中心细胞的肿瘤，占非霍奇金淋巴瘤的25%-40%。约三分之一的病例会转化为弥漫性大B细胞淋巴瘤（DLBCL）。CD5在B细胞慢性淋巴细胞白血病/小淋巴细胞淋巴瘤和套细胞淋巴瘤中表达，但在有充分记录的FL病例中，很少与CD10同时表达。本报告描述了1例1级FL病例，该病例在初诊6个月后转化为DLBCL，两种肿瘤均表达CD5。在两个标本中，几乎所有细胞中的肿瘤细胞CD20、CD79a、bcl-2、bcl-6和CD5均呈强阳性。CD10在初始标本中呈强阳性，在DLBCL中呈弱阳性。使用聚合酶链反应（PCR）进行的研究证实，DLBCL起源于FL，因为它们具有相同的免疫球蛋白重链基因重排和相同的BCL2-J(H)断点。
Zotero 插件