Tanaka M, Lee T C, Chichester C O
J Nutr. 1975 Aug;105(8):989-94. doi: 10.1093/jn/105.8.989.
The absorption of fructose-L-tryptophan, an early Maillard reaction product formed from tryptophan and glucose, in the large intestine of the rat was examined. The possible involvement of cecal microflora of the rat in the absorption of fructose-L-tryptophan was investigated. Fructose-L-tryptophan was degraded by the cecal microflora (in vitro) after a 12-hour incubation at 37 degrees. Experiments with rat colonic rings and everted sacs indicated that a passive diffusion of this compound occurs in vitro in the colon of the rat. In vivo absorption was determined by introducing fructose-L-[3-14C]tryptophan directly into the cecum. Twenty percent of the total radioactivity injected was recovered in the urine after 24 hours. Fructose-L-tryptophan was detected in the urine, which suggested that this compound was absorbed by the large intestine but excreted without being metabolized. Approximately 1% of the total radioactivity was recovered in the expired air within 24 hours after injection. The small recovery of fructose-L-tryptophan in feces might indicate that this compound was degraded by the action of microorganisms in the large intestine of the rat.
对大鼠大肠中果糖-L-色氨酸（一种由色氨酸和葡萄糖形成的早期美拉德反应产物）的吸收进行了研究。考察了大鼠盲肠微生物群在果糖-L-色氨酸吸收过程中可能发挥的作用。果糖-L-色氨酸在37℃下孵育12小时后被盲肠微生物群（体外）降解。大鼠结肠环和外翻肠囊实验表明，该化合物在大鼠结肠体外发生被动扩散。通过将果糖-L-[3-14C]色氨酸直接注入盲肠来测定体内吸收情况。24小时后，在尿液中回收了注入总放射性的20%。在尿液中检测到了果糖-L-色氨酸，这表明该化合物被大肠吸收但未代谢就被排出。注射后24小时内，在呼出气体中回收了约1%的总放射性。果糖-L-色氨酸在粪便中的回收率较低，这可能表明该化合物在大鼠大肠中被微生物作用降解。
