Hedstrand H, Ekwall O, Olsson M J, Landgren E, Kemp E H, Weetman A P, Perheentupa J, Husebye E, Gustafsson J, Betterle C, Kämpe O, Rorsman F
Department of Medical Sciences, University Hospital, S.E.-751 85, Uppsala, Sweden.
J Biol Chem. 2001 Sep 21;276(38):35390-5. doi: 10.1074/jbc.M102391200. Epub 2001 Jun 22.
Vitiligo is common in the hereditary disorder autoimmune polyendocrine syndrome type I (APS I). Patients with APS I are known to have high titer autoantibodies directed against various tissue-specific antigens. Using sera from APS I patients for immunoscreening of a cDNA library from human scalp, we identified the transcription factors SOX9 and SOX10 as novel autoantigens related to this syndrome. Immunoreactivity against SOX9 was found in 14 (15%) and against SOX10 in 20 (22%) of the 91 APS I sera studied. All patients reacting with SOX9 displayed reactivity against SOX10, suggesting shared epitopes. Among the 19 patients with vitiligo, 12 (63%) were positive for SOX10 (p < 0.0001). Furthermore, three of 93 sera from patients with vitiligo unrelated to APS I showed strong reactivity against SOX10, which may indicate a more general role of SOX10 as an autoantigen in vitiligo.
白癜风在遗传性疾病自身免疫性多内分泌综合征I型（APS I）中很常见。已知APS I患者具有针对各种组织特异性抗原的高滴度自身抗体。我们使用APS I患者的血清对人头皮的cDNA文库进行免疫筛选，鉴定出转录因子SOX9和SOX10是与该综合征相关的新型自身抗原。在所研究的91份APS I血清中，14份（15%）对SOX9有免疫反应性，20份（22%）对SOX10有免疫反应性。所有与SOX9反应的患者对SOX10也有反应性，表明存在共同表位。在19例白癜风患者中，12例（63%）SOX10呈阳性（p<0.0001）。此外，93份与APS I无关的白癜风患者血清中有3份对SOX10有强反应性，这可能表明SOX10作为自身抗原在白癜风中具有更普遍的作用。
