Robinson Agramonte M, Dorta-Contreras A J, Lorigados Pedre L
Departamento de Neuroinmunología; Centro Internacional de Restauración Neurológica (CIREN), La Habana, 11300, Cuba.
Rev Neurol. 2001;32(10):901-4.
Alzheimer s disease (AD) is a progressive degenerative disease affecting a significant proportion of the elderly population. The disease is characterized clinically by a progressive loss of memory function and mental impairment associated with the presence of degenerative well known pathological lesions. Although, the pathogenesis of AD is unclear; several reports indicate the involvement of immune factors.
This paper evaluates some cerebrospinal fluid immune markers from 21 patients with early and late AD and 20 age matched non-demented subjects. The analytical method included the evaluation of T cell subpopulations (using AcMc CD2, CD4, CD8) and activated T cells (AcMc HLA-DR and CD25) from CSF and peripheral blood by immunocytochemical techniques on a fixed cell slide as described by Bernd. The lymphocyte phenotype expressed as a percentage of positively stained cells for each cell surface marker evaluated.
Some significant differences were observed for T cell subpopulations from different compartments, between the different AD groups and the controls (p< 0.05). Nevertheless, the most significant differences were found in the activated T cells from cerebrospinal fluid between AD groups and controls (p< 0.01).
These results support the theory of neuroimmune dysregulation, probably involved in the progressive neurodegeneration and dementia in some AD.
阿尔茨海默病（AD）是一种进行性退行性疾病，影响着相当一部分老年人群体。该疾病在临床上的特征是记忆功能逐渐丧失以及与已知退行性病理病变相关的精神损害。尽管AD的发病机制尚不清楚，但有几份报告表明免疫因素参与其中。
本文评估了21例早发型和晚发型AD患者以及20例年龄匹配的非痴呆受试者的一些脑脊液免疫标志物。分析方法包括按照伯恩德所述，通过在固定细胞玻片上采用免疫细胞化学技术，对脑脊液和外周血中的T细胞亚群（使用抗人CD2、CD4、CD8）和活化T细胞（抗人HLA - DR和CD25）进行评估。淋巴细胞表型以每个评估的细胞表面标志物阳性染色细胞的百分比表示。
在不同AD组和对照组之间，不同区室的T细胞亚群存在一些显著差异（p < 0.05）。然而，AD组与对照组之间在脑脊液活化T细胞中发现了最显著差异（p < 0.01）。
这些结果支持神经免疫失调理论，该理论可能参与了部分AD患者的进行性神经退行性变和痴呆过程。
