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间日疟原虫血液期动态。

Plasmodium malariae blood-stage dynamics.

作者信息

McKenzie F E, Jeffery G M, Collins W E

机构信息

Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA.

出版信息

J Parasitol. 2001 Jun;87(3):626-37. doi: 10.1645/0022-3395(2001)087[0626:PMBSD]2.0.CO;2.

Abstract

We examine the dynamics of parasitemia, fever, and gametocytemia reflected in the preintervention charts of 180 malaria-naive U.S. neurosyphilis patients infected with the USPHS strain of Plasmodium malariae, for malariatherapy, focusing on the 84 charts for which more than 35 days of patency preceded intervention and daily records encompassed 92% or more of the duration of each infection. Inoculum size did not influence any outcome variable. Fevers (days with temperatures > or =101 F) followed patterns that fit recognized brood structures more often than did our approximations of merogony cycles (via local peaks in parasitemia), but neither closely fit textbook quartan patterns. There were no discernable patterns in gametocytemia. Successful transmission to mosquitoes increased following subcurative drug treatment but did not depend on detectable gametocytemia.

摘要

我们研究了180名初次感染疟疾的美国神经梅毒患者的干预前图表中所反映的疟原虫血症、发热和配子体血症的动态变化,这些患者感染了用于疟疾治疗的美国公共卫生服务(USPHS)株间日疟原虫,重点关注84份图表,这些图表在干预前有超过35天的虫血症期,且每日记录涵盖了每次感染持续时间的92%或更多。接种量不影响任何结果变量。发热(体温≥101华氏度的天数)所遵循的模式比我们通过疟原虫血症的局部峰值对裂殖生殖周期的近似更符合公认的虫期结构,但两者均未紧密符合教科书上的三日疟模式。配子体血症没有可辨别的模式。亚治愈性药物治疗后成功传播给蚊子的情况有所增加,但并不取决于可检测到的配子体血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a43/2483342/55f3e8a39d4c/nihms58079f1.jpg

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