发育中大鼠组织中组胺H(3)受体的表达分析。
Expression analysis of the histamine H(3) receptor in developing rat tissues.
作者信息
Héron A, Rouleau A, Cochois V, Pillot C, Schwartz J C, Arrang J M
机构信息
Laboratoire de Physiologie, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006, Paris, France.
出版信息
Mech Dev. 2001 Jul;105(1-2):167-73. doi: 10.1016/s0925-4773(01)00389-6.
Endogenous histamine is involved in tissue growth and cell proliferation. In accordance with a putative function of the H(3) receptor in this mitogenic effect, we show that H(3)-receptor mRNAs are expressed together with those of the histamine-synthesizing enzyme in the embryonic liver and adipose tissue, and in various epithelia. Finally, we show that activation of recombinant H(3) receptors enhances MAP kinase activity.
内源性组胺参与组织生长和细胞增殖。根据H(3)受体在这种促有丝分裂效应中的假定功能，我们发现H(3)受体mRNA与组胺合成酶的mRNA在胚胎肝脏、脂肪组织以及各种上皮组织中共同表达。最后，我们发现重组H(3)受体的激活增强了丝裂原活化蛋白激酶（MAP激酶）的活性。
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