Tribe R M
Maternal and Fetal Research Unit, Division of Women and Children's Health, Guy's, King's and St Thomas' School of Medicine, St Thomas' Hospital Campus, London SE1 7EH, UK.
Exp Physiol. 2001 Mar;86(2):247-54. doi: 10.1113/eph8602180.
If we are to develop new strategies for the treatment and management of preterm and dysfunctional term labour, it is imperative that we improve current understanding of the control of human uterine activity. Despite many studies of animal pregnancy, there is a paucity of knowledge relating to the complex control of human myometrium during pregnancy. It is hypothesized that human myometrium is relatively quiescent during the majority of pregnancy and that as term approaches there is cascade of molecular events that prepare the uterus for labour. This review will consider the cellular mechanisms involved in the regulation of human myometrial activity and the modulation of these by hormonal and mechanical signals. In particular, the contribution of calcium homeostatic pathways to the control of human myometrial contractility during gestation will be discussed. Experimental Physiology (2001) 86.2, 247-254.
如果我们要开发早产和足月功能失调性分娩的治疗与管理新策略，那么提高当前对人类子宫活动控制的理解就势在必行。尽管对动物妊娠进行了许多研究，但关于妊娠期间人类子宫肌层复杂控制的知识却很匮乏。据推测，在妊娠的大部分时间里，人类子宫肌层相对静止，而随着足月临近，会有一系列分子事件发生，使子宫为分娩做好准备。本综述将探讨参与调节人类子宫肌层活动的细胞机制以及激素和机械信号对这些机制的调节作用。特别是，将讨论钙稳态途径在妊娠期对人类子宫肌层收缩性控制中的作用。《实验生理学》（2001年）86.2，247 - 254页。
