Degli Esposti E, Sturani A, Degli Esposti L, Macini P L, Falasca P, Valpiani G, Buda S
Ravenna Local Health Unit, Department of Nephrology, S.M. delle Croci Hospital, Italy.
Int J Clin Pharmacol Ther. 2001 Jun;39(6):251-8.
To identify clinical and economic indicators of pharmacoutilization of antihypertensive drugs.
4614 subjects receiving a first prescription for amlodipine, atenolol, fosinopril, indapamide, or losartan were included in the study. All prescriptions filled during the study period from January 1, 1997 to December 31, 1998 were considered. A retrospective analysis was carried out on information recorded in the drug database. The percentage of patients continuing, discontinuing, and switching the initial treatment, duration of treatment, and doses used were calculated together with total costs.
A large proportion of patients (65.1%) discontinued the treatment. From the analysis of the mean daily dose taken by patients who continued the treatment, it was found that many subjects took a drug dosage which was below the therapeutic dose range, whereas the administration of doses above the therapeutic range occurred only occasionally. Continuation of treatment accounted for 48.1% of total costs, switching accounted for 20.8%, and discontinuation represented 31.1% of total expenditures.
With adequate markers, helpful data can be collected for monitoring the quality of antihypertensive drug prescriptions and the rational usage of resources in the general practice setting.
确定抗高血压药物药物利用的临床和经济指标。
本研究纳入了4614名首次接受氨氯地平、阿替洛尔、福辛普利、吲达帕胺或氯沙坦处方的受试者。研究考虑了1997年1月1日至1998年12月31日研究期间开出的所有处方。对药物数据库中记录的信息进行了回顾性分析。计算了继续、停用和更换初始治疗的患者百分比、治疗持续时间、使用剂量以及总成本。
很大一部分患者（65.1%）停止了治疗。通过对继续治疗患者的平均日剂量分析发现，许多受试者服用的药物剂量低于治疗剂量范围，而高于治疗范围的剂量给药仅偶尔发生。继续治疗占总成本的48.1%，换药占20.8%，停药占总支出的31.1%。
通过适当的指标，可以收集有用的数据来监测抗高血压药物处方质量以及全科医疗环境中资源的合理使用情况。
