Millet A, Pasqualini J R
C R Acad Hebd Seances Acad Sci D. 1978 Dec;287(16):1429-32.
The presence of a protein that binds specifically and with high affinity to progesterone is found in the plasma of fetal guinea Pig. Progesterone and 5 alpha-dihydroxyprogesterone strongly compete for the 3H-progesterone-protein complex. 5 beta-dihydroxy progesterone, 20 beta-dihydroxyprogesterone, testosterone and synthetic progestagen, R-5020 (17,21-dimethyl-19-norpregna-4, 9-diene-3,20 dione), also compete but less intensely. 17-hydroxyprogesterone, aldosterone, cortisol, oestradiol and oestrone have no effect. The 3H-progesterone-protein, complex has an affinity of Kd = 8.8 +/- 3.5 x 10(-10) M and in sucrose density gradient the sedimentation coefficient is 4.6 S.
在豚鼠胎儿血浆中发现一种能与孕酮特异性且高亲和力结合的蛋白质。孕酮和5α-二羟孕酮能强烈竞争3H-孕酮-蛋白质复合物。5β-二羟孕酮、20β-二羟孕酮、睾酮及合成孕激素R-5020（17,21-二甲基-19-去甲孕-4,9-二烯-3,20-二酮）也能竞争，但强度较弱。17-羟孕酮、醛固酮、皮质醇、雌二醇和雌酮则无影响。3H-孕酮-蛋白质复合物的亲和力Kd = 8.8 +/- 3.5 x 10(-10) M，在蔗糖密度梯度中的沉降系数为4.6 S。
