Kimura H, Hoshino Y, Kanegane H, Tsuge I, Okamura T, Kawa K, Morishima T
Department of Pediatrics, Nagoya University Graduate School of Medicine, Japan.
Blood. 2001 Jul 15;98(2):280-6. doi: 10.1182/blood.v98.2.280.
Thirty patients with chronic active Epstein-Barr virus (CAEBV) infection were analyzed. The study group included 18 male and 12 female patients, ranging in age from 5 to 31 years with a mean age of 14.2 years. Not all patients had high titers of EBV-specific antibodies, but all patients had high viral loads in their peripheral blood (more than 10(2.5) copies/microg DNA). Fifty percent of the patients displayed chromosomal aberrations, and 79% had monoclonality of EBV. Patients were divided into 2 clinically distinct groups, based on whether the predominantly infected cells in their peripheral blood were T cells or natural killer (NK) cells. Over a 68-month period of observation, 10 patients died from hepatic failure, malignant lymphoma, or other causes. Patients with T-cell CAEBV had a shorter survival time than those with NK-cell type of disease.
对30例慢性活动性EB病毒（CAEBV）感染患者进行了分析。研究组包括18例男性和12例女性患者，年龄在5至31岁之间，平均年龄为14.2岁。并非所有患者都有高滴度的EBV特异性抗体，但所有患者外周血中的病毒载量都很高（超过10(2.5)拷贝/微克DNA）。50%的患者出现染色体畸变，79%的患者EBV呈单克隆性。根据外周血中主要感染的细胞是T细胞还是自然杀伤（NK）细胞，将患者分为2个临床不同的组。在68个月的观察期内，10例患者死于肝衰竭、恶性淋巴瘤或其他原因。T细胞型CAEBV患者的生存时间比NK细胞型疾病患者短。
