Vukovich M D, Stubbs N B, Bohlken R M
South Dakota State University, Brookings, SD 57007, USA.
J Nutr. 2001 Jul;131(7):2049-52. doi: 10.1093/jn/131.7.2049.
Studies in young adults have demonstrated that beta-hydroxy-beta-methylbutyrate (HMB) can increase gains in strength and fat-free mass during a progressive resistance-training program. The purpose of this study was to determine whether HMB would similarly benefit 70-y-old adults undergoing a 5 d/wk exercise program. Thirty-one men (n = 15) and women (n = 16) (70 +/- 1 y) were randomly assigned in a double-blind study to receive either capsules containing a placebo or Ca-HMB (3 g/d) for the 8-wk study. Skin fold estimations of body composition as well as computerized tomography (CT) and dual X-ray absorptiometry (DXA) scans were measured before the study and immediately after the 8-wk training program. HMB supplementation tended to increase fat-free mass gain (HMB, 0.8 +/- 0.4 kg; placebo, -0.2 +/- 0.3 kg; treatment x time, P = 0.08). Furthermore, HMB supplementation increased the percentage of body fat loss (skin fold: HMB, -0.66 +/- 0.23%; placebo, -0.03 +/- 0.21%; P = 0.05) compared with the placebo group. CT scans also indicated a greater decrease in the percentage of body fat with HMB supplementation (P < 0.05). In conclusion, changes in body composition can be accomplished in 70-y-old adults participating in a strength training program, as previously demonstrated in young adults, when HMB is supplemented daily.
针对年轻人的研究表明，在进行渐进性抗阻训练计划期间，β-羟基-β-甲基丁酸酯（HMB）可增加力量和去脂体重的增长。本研究的目的是确定HMB对参与每周5天锻炼计划的70岁成年人是否同样有益。在一项双盲研究中，31名男性（n = 15）和女性（n = 16）（70±1岁）被随机分配，在为期8周的研究中接受含安慰剂的胶囊或钙-HMB（3克/天）。在研究开始前以及8周训练计划结束后立即测量身体成分的皮褶估计值以及计算机断层扫描（CT）和双能X线吸收法（DXA）扫描。补充HMB倾向于增加去脂体重的增加（HMB组，0.8±0.4千克；安慰剂组，-0.2±0.3千克；治疗×时间，P = 0.08）。此外，与安慰剂组相比，补充HMB增加了体脂减少的百分比（皮褶：HMB组，-0.66±0.23%；安慰剂组，-0.03±0.21%；P = 0.05）。CT扫描也表明补充HMB后体脂百分比下降幅度更大（P < 0.05）。总之，70岁成年人参与力量训练计划时，身体成分的变化可以实现，这与之前在年轻人中所证明的情况一样，即每天补充HMB。
