Gragnoli G, Puccetti F, Tanganelli I, Favilli R, Nami R
Minerva Med. 1975 Apr 21;66(30):1412-6.
The antihypertensive effect and the tolerance of the association of spironolactone and chlorthalidone were evaluated clinically and by numerous laboratory examinations in a group of 18 patients affected with non-complicated essential hypertension. All the patients were treated for 30 consecutive days with chlorthalidone (100 mg/day) and then for another 30 days with the two drugs administered contemporaneously (100 mg/day of spironolactone + 100 mg/day chlorthalidone). The balanced combination of the two drugs showed to be significantly more active than the treatment with just chlorthalidone and the margin of safety wider; the therapeutic activity showed to be independent from the variations of the plasma renin activity.
在一组18例患有非复杂性原发性高血压的患者中，通过临床评估和多项实验室检查，对螺内酯和氢氯噻嗪联合用药的降压效果及耐受性进行了研究。所有患者先连续30天服用氢氯噻嗪（100毫克/天），然后再连续30天同时服用两种药物（螺内酯100毫克/天 + 氢氯噻嗪100毫克/天）。两种药物的均衡组合显示出比单用氢氯噻嗪治疗显著更有效，且安全范围更宽；治疗活性显示与血浆肾素活性的变化无关。
