Cox R A, Rao P, Brandon-Cox C
Kettering General Hospital, Rothwell Road, Kettering, Northants NN16 8UZ, UK.
J Hosp Infect. 2001 Jul;48(3):186-92. doi: 10.1053/jhin.2001.1002.
An outbreak of respiratory syncytial virus (RSV) infection affected seven premature infants in a special care baby unit during November and December 1999. Conventional infection control measures (cohorting infected babies, strict reinforcement of the use of gloves and aprons, emphasis on hand disinfection) failed to prevent spread. Palivizumab, a respiratory syncytial virus monoclonal antibody, was given to eight high-risk preterm infants. There were no further cases of RSV in the unit and none of the babies given palivizumab developed RSV. One baby who acquired RSV during the outbreak (and who was not given palivizumab) was subsequently admitted to hospital with another episode of RSV bronchiolitis. The role of palivizumab in the control of hospital outbreaks of RSV infection merits further investigation.
1999年11月至12月期间，一家特殊护理婴儿病房爆发呼吸道合胞病毒（RSV）感染，影响了7名早产儿。传统的感染控制措施（将感染婴儿集中护理、严格加强手套和围裙的使用、强调手部消毒）未能阻止病毒传播。给8名高危早产儿使用了呼吸道合胞病毒单克隆抗体帕利珠单抗。该病房未再出现RSV病例，接受帕利珠单抗治疗的婴儿均未感染RSV。1名在疫情期间感染RSV（未接受帕利珠单抗治疗）的婴儿随后因再次发作RSV细支气管炎而住院。帕利珠单抗在控制医院内RSV感染暴发中的作用值得进一步研究。
