Infection Control, Hospital e Maternidade Santa Joana, Rua do Paraíso 432, São Paulo, SP, 04103-000, Brazil.
Antimicrob Resist Infect Control. 2012 May 2;1(1):16. doi: 10.1186/2047-2994-1-16.
The occurrence of a respiratory syncytial virus (RSV) outbreak in a Neonatal Intensive Care Unit (NICU) is related to unfavorable outcomes, as this infection can lead to respiratory distress and death in premature in infants. Report the successful control of an outbreak that occurred in April 2010 in a NICU.
After the index case, of 18 premature infants placed in the same room 10 infants were infected. Of those 10, 6 developed mild to moderate respiratory symptoms, 4 persisted asymptomatic and no death occurred. Contact and respiratory precautions were rapidly initiated, the infants were cohorted in 3 different rooms and palivizumab was administered to all contacts.
The outbreak was controlled and no new cases were subsequently indentified.
Standard infection control measures plus palivizumab prophylaxis were efficient in rapid control of the outbreak.
新生儿重症监护病房（NICU）发生呼吸道合胞病毒（RSV）爆发与不良结局相关，因为这种感染可导致早产儿呼吸窘迫和死亡。报告 2010 年 4 月在 NICU 成功控制的一次爆发。
在首例病例后，有 18 名早产儿安置在同一间病房，其中 10 名婴儿受到感染。这 10 名婴儿中，6 名出现轻度至中度呼吸症状，4 名持续无症状，无死亡发生。迅速启动接触和呼吸道防护措施，将婴儿分组安置在 3 个不同的房间，并对所有接触者使用帕利珠单抗。
爆发得到控制，此后未再发现新病例。
标准感染控制措施加用帕利珠单抗预防对快速控制爆发有效。
