Pary R J
Southern Illinois University, School of Medicine, Department of Psychiatry, Springfield 62794-9230.
Ment Retard. 1994 Oct;32(5):323-7.
Few investigators have focused on the response of individuals with mental retardation to clozapine. In the general population, some people who have responded to no other psychotropic have had a tremendous positive response, including increased positive scores "quality of life" measures. Clozapine, however, can cause fatal side effects. At least six people in the United States have died from agranulocytosis despite weekly blood counts. The use of clozapine in the general population was reviewed, potential difficulties in prescribing it for individuals with mental retardation discussed, and three relevant case histories presented.
很少有研究者关注智力迟钝者对氯氮平的反应。在普通人群中，一些对其他精神药物均无反应的人对氯氮平却有极大的积极反应，包括在“生活质量”测量中的阳性得分增加。然而，氯氮平可导致致命的副作用。在美国，尽管每周进行血常规检查，仍至少有六人死于粒细胞缺乏症。本文回顾了氯氮平在普通人群中的使用情况，讨论了为智力迟钝者开此药时可能存在的困难，并列举了三个相关病例。
