福司曲星C1-C12片段的合成。
Synthesis of the C1-C12 fragment of fostriecin.
作者信息
Cossy J, Pradaux F, BouzBouz S
机构信息
Laboratoire de Chimie Organique associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 - Paris Cedex 05, France.
出版信息
Org Lett. 2001 Jul 12;3(14):2233-5. doi: 10.1021/ol016116x.
PMID:11440587
Abstract
[reaction: see text] The synthesis of the C(1)-C(12) fragment of fostriecin was achieved from (S)-glycidol in 15 steps by using an enantioselective allytitanation reaction and a ring-closure metathesis as the key steps.
摘要
[反应：见正文] 以（S）-缩水甘油为原料，通过对映选择性烯丙基钛化反应和闭环复分解反应作为关键步骤，经15步反应实现了福司曲星C(1)-C(12)片段的合成。
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