Trost Barry M, Knopf Joshua D, Brindle Cheyenne S
Department of Chemistry, Stanford University , Stanford, California 94305-5080, United States.
Department of Chemistry, Trinity College , 300 Summit Street, Hartford, Connecticut 06106, United States.
Chem Rev. 2016 Dec 28;116(24):15035-15088. doi: 10.1021/acs.chemrev.6b00488. Epub 2016 Dec 8.
Fostriecin and related natural products present a significant challenge for synthetic chemists due to their structural complexity and chemical sensitivity. This review will chronicle the successful efforts of synthetic chemists in the construction of these biologically active molecules. Key carbon-carbon bond forming reactions will be highlighted, as well as the methods used to install the numerous stereocenters present in this class of compounds.
由于其结构复杂性和化学敏感性，磷霉素及相关天然产物对合成化学家构成了重大挑战。本综述将按时间顺序记述合成化学家在构建这些生物活性分子方面所取得的成功努力。将重点介绍关键的碳 - 碳键形成反应，以及用于构建这类化合物中众多立体中心的方法。
