White C M, Fan C, Song J, Tsikouris J P, Chow M
Department of Pharmacy, Hartford Hospital, Connecticut, 06102-5037, USA.
Pharmacotherapy. 2001 Jul;21(7):773-7. doi: 10.1592/phco.21.9.773.34561.
To compare the hemostatic effects of hydrophilic, alcohol, or lipophilic extract of notoginseng with those of the control and placebo.
Hemorrhagic rat model.
Hartford Hospital, Hartford, Connecticut; animals were housed at the Hartford Hospital animal facility.
Sixty-two male Wistar rats. Intervention. Administration of placebo (wheat flour), and alcohol, hydrophilic (water), and lipophilic (hexane) extracts of notoginseng.
Rats were divided into five groups, and their tails were transected 5 mm from the tip. Group 1 received no treatment (control), group 2 received placebo, group 3 received alcohol extract, group 4 received hydrophilic extract, and group 5 received lipophilic extract. Total bleeding time was determined and compared among the groups.
Bleeding time was shorter for the placebo group than the control group (p=0.035). The alcohol extract group had the shortest bleeding time, which was significantly shorter than that of the control (p<0.0001), placebo (p=0.0124), and lipophilic extract groups (p=0.002). The hydrophilic extract group had a shorter bleeding time than the control group (p=0.0058) and showed a trend toward shorter bleeding time than the lipophilic extract group (p=0.068).
The alcohol extract of notoginseng results in the shortest bleeding time and provides better hemostatic effects than no treatment, placebo treatment, and treatment with lipophilic extract.
比较三七亲水性提取物、醇提取物或脂溶性提取物与对照组及安慰剂的止血效果。
出血性大鼠模型。
康涅狄格州哈特福德市哈特福德医院；动物饲养于哈特福德医院动物设施内。
62只雄性Wistar大鼠。干预措施：给予安慰剂（小麦粉）、三七醇提取物、亲水性提取物（水提取物）和脂溶性提取物（己烷提取物）。
将大鼠分为五组，从尾尖起5毫米处横断其尾巴。第1组不接受任何处理（对照组），第2组接受安慰剂，第3组接受醇提取物，第4组接受亲水性提取物，第5组接受脂溶性提取物。测定并比较各组的总出血时间。
安慰剂组的出血时间比对照组短（p = 0.035）。醇提取物组的出血时间最短，显著短于对照组（p < 0.0001）、安慰剂组（p = 0.0124）和脂溶性提取物组（p = 0.002）。亲水性提取物组的出血时间比对照组短（p = 0.0058），且有比脂溶性提取物组出血时间更短的趋势（p = 0.068）。
三七醇提取物导致的出血时间最短，与不治疗、安慰剂治疗及脂溶性提取物治疗相比，具有更好的止血效果。
