Sönmez Ertan, Cavuş Umut Yücel, Civelek Cemil, Dur Ali, Karayel Eda, Gülen Bedia, Uysal Omer, Ipek Göktürk
Department of Emergency Medicine, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey.
Department of Emergency Medicine, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.
Ulus Travma Acil Cerrahi Derg. 2014 Mar;20(2):79-85. doi: 10.5505/tjtes.2014.54938.
Bleeding is a major problem in warfarin pretreated patients who need emergency surgical procedures. APH is a hemostatic agent with ultra-hydrophilic and particulate properties. This study aimed to evaluate the in vivo hemostatic effect of APH in rats pretreated with warfarin.
Forty-eight Wistar rats were divided into two main groups: one group was pretreated with warfarin and the other group was not. These two groups were further divided into three subgroups according to the administration of APH, wheat meal, or saline, for a total of six subgroups. Standard full thickness tissue defects were performed on the backs of the rats. Saline, wheat meal, or APH were administered to the bleeding defect site in both main groups. Hemostasis time and amount of bleeding were calculated.
The bleeding time in rats administered APH was significantly shorter than those administered wheat meal and saline. Consequently, the amount of bleeding was significantly less in the APH groups than in the control groups.
APH has an effective hemostatic property in rats pretreated or non-pretreated with anticoagulants. Hemostatic agents can be useful for incidences of external bleedings, which are increasing because of anticoagulation.
对于需要进行急诊手术的华法林预处理患者而言，出血是一个主要问题。APH是一种具有超亲水性和颗粒特性的止血剂。本研究旨在评估APH在华法林预处理大鼠体内的止血效果。
48只Wistar大鼠被分为两个主要组：一组用华法林预处理，另一组未进行预处理。这两组再根据APH、麦粉或生理盐水的给药情况进一步分为三个亚组，总共六个亚组。在大鼠背部制造标准的全层组织缺损。在两个主要组中，将生理盐水、麦粉或APH施用于出血缺损部位。计算止血时间和出血量。
给予APH的大鼠出血时间明显短于给予麦粉和生理盐水的大鼠。因此，APH组的出血量明显少于对照组。
APH在抗凝预处理或未预处理的大鼠中具有有效的止血特性。止血剂对于因抗凝导致的外部出血情况可能有用。
