经L-色氨酸处理的大鼠对电击的敏感性未改变。

Unchanged sensitivity to electric shock in L-tryptophan treated rats.

作者信息

Hole K, Marsden C A

出版信息

Pharmacol Biochem Behav. 1975 Mar-Apr;3(2):307-9. doi: 10.1016/0091-3057(75)90162-8.

Abstract

Injections of L-tryptophan (50, 100 and 200 mg/kg) i.p. in rats resulted in dose dependent increases in brain concentrations of tryptophan, 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Sensitivity to electric shock as measured by flinch and jump thresholds was not changed by L-tryptophan 100 and 200 mg/kg. The results indicate that increased 5-HT turnover does not influence sensitivity to electric shock.

摘要

腹腔注射给予大鼠不同剂量（50、100和200毫克/千克）的L-色氨酸后，大鼠脑内色氨酸、5-羟色胺和5-羟吲哚乙酸的浓度呈剂量依赖性增加。通过退缩和跳跃阈值测量的对电击的敏感性，在注射100毫克/千克和200毫克/千克L-色氨酸后并未改变。结果表明，5-羟色胺（5-HT）代谢增加并不影响对电击的敏感性。