Tachibana T, Matsuyama T, Ito M, Mitsuyama M
Department of Bacteriology Niigata University School of Medicine, Japan.
Med Mycol. 2001 Jun;39(3):295-8. doi: 10.1080/mmy.39.3.295.298.
Four mutants of the Sporothrix schenckii lung isolate IFM 41598 were isolated by their inability to form colonies on a Sabouraud glucose agar plate incubated at 37 degrees C for 4 days. In contrast to the parent IFM 41598, these thermo-intolerant mutants were all defective in producing fatal visceral infections in mice, even though they retained infectivity in footpad tissues with a small fungal inoculum (approximately equals 10 cfu).
申克孢子丝菌肺分离株IFM 41598的四个突变体，是通过它们在37℃孵育4天的沙氏葡萄糖琼脂平板上无法形成菌落而分离得到的。与亲本IFM 41598相比，这些不耐热突变体在小鼠体内产生致命内脏感染方面均存在缺陷，尽管它们在接种少量真菌（约等于10 cfu）的足垫组织中仍保持感染性。
