Morales Cifuentes C, Gómez-Serranillos M P, Iglesias I, Villar del Fresno A M, Morales C, Paredes M E, Cáceres A
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
J Ethnopharmacol. 2001 Aug;76(3):223-8. doi: 10.1016/s0378-8741(01)00235-5.
We carried out the Irwin's test with some different extracts of the aerial parts of Thidax procumbens L., the leaves of Neurolaena lobata (L.) R. Br., bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp., and root and leaves of Petiveria alliacea L. At dosage of 1.25 g dried plant/kg weight aqueous extracts of bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp. demonstrated the most activity: decrease in motor activity, back tonus, reversible parpebral ptosis, catalepsy and strong hypothermia. These extracts of both plants were assayed for effects on CNS and they caused very significant reductions in spontaneous locomotor activity, exploratory behavior and rectal temperature and they increased the sodium pentobarbital-induced sleeping time.
我们用平卧蒂达克斯（Thidax procumbens L.）地上部分的不同提取物、羽叶纽罗莱纳（Neurolaena lobata (L.) R. Br.）的叶子、厚叶比森尼木（Byrsonima crassifolia (L.) Kunth.）的树皮和叶子、南美槐（Gliricidia sepium Jacq. Walp.）以及蒜臭草（Petiveria alliacea L.）的根和叶子进行了欧文氏试验。在剂量为1.25克干燥植物/千克体重时，厚叶比森尼木（Byrsonima crassifolia (L.) Kunth.）和南美槐（Gliricidia sepium Jacq. Walp.）的树皮和叶子的水提取物表现出最强活性：运动活性降低、背部紧张度降低、可逆性眼睑下垂、僵住症和明显体温过低。对这两种植物的这些提取物进行了对中枢神经系统影响的测定，它们使自发运动活性、探究行为和直肠温度显著降低，并延长了戊巴比妥钠诱导的睡眠时间。
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