来自……种子的比索尼二醇的抗炎作用 。 你提供的原文似乎不完整，“from seeds of.”后面缺少具体内容。
Anti-inflammatory effect of birsonimadiol from seeds of .
作者信息
Pérez Gutiérrez Rosa Martha
机构信息
Research Laboratory of Natural Products, School of Chemical Engineering, National Polytechnic Institute, Av. Instituto Politecnico Nacional S/N, Unidad Profesional Adolfo Lopez Mateos, Zacatenco, D.F. CP07758 Mexico.
出版信息
Food Sci Biotechnol. 2016 Apr 30;25(2):561-566. doi: 10.1007/s10068-016-0078-7. eCollection 2016.
The new compound identified as 16α,23α-dihydroxy-3β,28β,30α-triacetoxy-olean-12-ene, named birsonimadiol (BIR) was isolated from seeds using activity-guided fractionation and structural elucidation was achieved based on extensive analysis of spectroscopic data. Effects of BIR on acute and chronic phases of inflamation were studied in edema induced using formaldehyde, 12-O-tetradecanoylphorbol-acetate (TPA)-induced ear edema (meloperoxidase activity), and histamine, carrageenan, cotton pellet granuloma, and adjuvant-induced arthritis. Anti-inflammatory activities of BIR were indicated based on reduction of edema levels induced in models of inflammation. Anti-inflammatory activities were also investigated in murine macrophage RAW264.7 cells. BIR suppressed production of nitric oxide (NO) and prostaglandin E (PGE), decreased gene expression of cyclooxygenase-2 (COX-2), inhibited tumor necrosis factor (TNF)-α, and protein secretion of interleukin IL-6. Triterpene was an effective topical anti-inflammatory agent in experimental models of acute and chronic dermatitis and can be used in inflammatory disorders.
新化合物被鉴定为16α,23α - 二羟基 - 3β,28β,30α - 三乙酰氧基 - 齐墩果 - 12 - 烯，命名为比索尼二醇（BIR），通过活性导向分级分离法从种子中分离得到，并基于光谱数据的广泛分析实现了结构解析。在甲醛诱导的水肿、12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA）诱导的耳水肿（髓过氧化物酶活性）以及组胺、角叉菜胶、棉球肉芽肿和佐剂诱导的关节炎模型中，研究了BIR对炎症急性期和慢性期的影响。基于炎症模型中诱导的水肿水平降低，表明了BIR的抗炎活性。还在小鼠巨噬细胞RAW264.7细胞中研究了其抗炎活性。BIR抑制一氧化氮（NO）和前列腺素E（PGE）的产生，降低环氧化酶 - 2（COX - 2）的基因表达，抑制肿瘤坏死因子（TNF） - α以及白细胞介素IL - 6的蛋白分泌。三萜类化合物在急性和慢性皮炎的实验模型中是一种有效的局部抗炎剂，可用于炎症性疾病。
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