Deshayes P, Thomine J M, Hemet J, Seruzier E, Biga N, Ducastelle C
Rev Rhum Mal Osteoartic. 1975 May;42(5):345-53.
Coxopathies with rapid chondrolysis: Comparison of clinical and anatomical findings. Clinical, radiological, laboratory, and antomical data concerning 14 coxopathies with rapid chodrolysis are presented with reference to 12 patients aged from 37 to 77 years. Three criteria define this affection: reduction of the joint space by at least 50 per cent, in one year or less; chondrolysis completed in 1 to 3 years; complete narrowing in the superior part of the joint; isolated narrowing, exceptionally with a discrete osteophytosis. The pain rapidly becomes very severe. Such symptoms are, at first, indicative of coxitis, but the establishment of a radio-clinical picture of coxopathy rapid chrondrolysis is more indicative of an arthrosic origin. This could represent a particular evolutive stage of coxarthrosis related to the initial chondrolytic phase of rapid destructive coxarthrosis. From an early stage, the anatomical facts indicate an association between the degenerative lesions and the non-specific inflammatory lesions of the synovial membrane. These facts are interpreted, on the basis of data in the literature, as an indication of synovial lesions caused by the liberation of osteocartilaginous fragments. The problem of the pathogenesis of this rapid chondrolysis is then discussed.
临床与解剖学发现比较。本文呈现了14例伴有快速软骨溶解的髋关节炎患者（年龄从37岁至77岁）的临床、放射学、实验室及解剖学数据。定义该病症有三个标准：关节间隙在一年或更短时间内至少减少50%；软骨溶解在1至3年内完成；关节上部完全狭窄；孤立狭窄，极少数伴有离散性骨赘形成。疼痛迅速变得非常严重。此类症状起初提示髋关节炎，但伴有快速软骨溶解的髋关节炎的放射学 - 临床图像的形成更提示关节病起源。这可能代表与快速破坏性髋关节炎初始软骨溶解期相关的髋关节炎的一个特定演变阶段。从早期开始，解剖学事实表明退变病变与滑膜非特异性炎性病变之间存在关联。基于文献数据，这些事实被解释为骨软骨碎片释放导致滑膜病变的迹象。随后讨论了这种快速软骨溶解的发病机制问题。
