Cordier A C, Heremans J F
Scand J Immunol. 1975;4(2):193-6. doi: 10.1111/j.1365-3083.1975.tb02616.x.
Sterile female homozygous nude mice were rendered fertile through a graft of thymic epithelium from heterozygous littermates 3 days after birth. Homozygous nude embryos were compared with embryos age (8-18 days). In nude mice, the embryological anomaly is noticeable from the 11th day of gestation and essentially consists of a failure of the ectoderm from the 3rd branchial cleft to proliferate and differentiate into a cervical vesicle. As a result, the endoderm from the 3rd pouch degenerates into cystic formations instead of differentiating.
出生3天后，通过移植来自杂合子同窝仔鼠的胸腺上皮，使无菌雌性纯合裸鼠恢复生育能力。将纯合裸鼠胚胎与8至18天龄的胚胎进行比较。在裸鼠中，胚胎学异常从妊娠第11天开始明显，主要表现为第三鳃裂的外胚层未能增殖并分化为颈囊。结果，第三咽囊的内胚层退化为囊性结构，而不是分化。
