Natali P G, Nicotra M R, Giacomini P, Pellegrino M A, Ferron S
Immunogenetics. 1981;14(5):359-65. doi: 10.1007/BF00373316.
The ontogeny of I-Ak antigens in murine tissues of nonlymphoid origin has been evaluated by reacting acetone-fixed cryostat sections of embryonic, neonate, and adult tissues with the MOAb 10-2.16 in indirect immunofluorescence. Thymus dendritic cells appear to be the first to express I-Ak antigens which become detectable only after birth in skin Langerhans cells, gastrointestinal epithelium, septal cells in lung alveoli, and some endothelia. The full expression of I-Ak antigens as detected in adult mice is reached only at 1 month of age.
通过用单克隆抗体10-2.16对胚胎、新生和成年组织的丙酮固定冰冻切片进行间接免疫荧光反应，评估了非淋巴起源的小鼠组织中I-Ak抗原的个体发生。胸腺树突状细胞似乎是最早表达I-Ak抗原的细胞，而皮肤朗格汉斯细胞、胃肠道上皮、肺泡间隔细胞和一些内皮细胞中的I-Ak抗原在出生后才变得可检测到。成年小鼠中检测到的I-Ak抗原的完全表达直到1月龄时才达到。
