Norrby R, Eilard T, Svedhem A, Lycke E
Scand J Infect Dis. 1975;7(1):72-5. doi: 10.3109/inf.1975.7.issue-1.13.
Toxoplasmosis is known to complicate diseases with impaired cellular immunity. For treatment of toxoplasma infections atoxic drugs should be used to avoid depression of the bone marrow. The hitherto recommended treatment, pyrimethamine in combination with sulphonamides, is often associated with severe side-effects. The present study presents the results of treatment with trimethoprim and sulphamethoxazole in 7 patients, clinically and serologically diagnosed as having toxoplasmosis. Good therapeutic results were observed in 5 patients with lymphoglandular toxoplasmosis and a significant reduction of the dye test titres were found in 6 patients. In one patient, however, a relapse of clinical symptoms and a reversion to high dye test titres were observed 6 1/2 months after the end of the treatment. Treatment had to be discontinued in one patient due to an allergic reaction.
已知弓形虫病会使细胞免疫受损的疾病复杂化。治疗弓形虫感染时应使用无毒药物，以避免抑制骨髓。迄今为止推荐的治疗方法，即乙胺嘧啶与磺胺类药物联合使用，常常伴有严重的副作用。本研究呈现了7例临床和血清学诊断为弓形虫病的患者使用甲氧苄啶和磺胺甲恶唑治疗的结果。5例淋巴结型弓形虫病患者取得了良好的治疗效果，6例患者的染料试验滴度显著降低。然而，有1例患者在治疗结束6个半月后出现临床症状复发，染料试验滴度又回升至高水平。有1例患者因过敏反应而不得不停止治疗。
