Khaw M, Panosian C B
Division of Infectious Diseases, UCLA School of Medicine 90024-1688, USA.
Clin Microbiol Rev. 1995 Jul;8(3):427-39. doi: 10.1128/CMR.8.3.427.
Human protozoal infections are ubiquitous and occur worldwide. In many cases, antiprotozoal agents currently in use predate the modern antibiotic era. Despite the relative lag in development of new antiprotozoal agents, the 1990s have witnessed an increasing level of interest in these infections, inspired by international travel and immigration, a growing awareness of antiprotozoal drug resistance, and the significance of acute and recrudescent protozoal infections in immunosuppressed hosts. This review summarizes for nonclinician readers the past, present, and future therapies for common human protozoal infections, as well as pharmacologic mechanisms of action and resistance and common toxicities associated with these agents.
人类原生动物感染普遍存在,在全球范围内都有发生。在许多情况下,目前使用的抗原生动物药物早在现代抗生素时代之前就已存在。尽管新抗原生动物药物的研发相对滞后,但受国际旅行和移民、对抗原生动物耐药性认识的不断提高以及免疫抑制宿主中急性和复发性原生动物感染的重要性的影响,20世纪90年代人们对这些感染的兴趣日益浓厚。这篇综述为非临床医生读者总结了常见人类原生动物感染的过去、现在和未来的治疗方法,以及这些药物的药理作用机制、耐药性和常见毒性。