Kretschmar M, Geginat G, Bertsch T, Walter S, Hof H, Nichterlein T
Institut für Medizinische Mikrobiologie und Hygiene, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, 68167 Mannheim, Germany.
Antimicrob Agents Chemother. 2001 Aug;45(8):2383-5. doi: 10.1128/AAC.45.8.2383-2385.2001.
Liposomal amphotericin B was immunosuppressive on target cell lysis in vitro and on protection mediated by cytotoxic CD8 T cells in murine listeriosis. When dosages usually used for therapy in humans were compared, the immunosuppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/day was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosage of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.
脂质体两性霉素B在体外对靶细胞裂解具有免疫抑制作用,在鼠类李斯特菌病中对细胞毒性CD8 T细胞介导的保护作用也有免疫抑制作用。当比较通常用于人类治疗的剂量时,5毫克脂质体两性霉素B/千克体重/天的免疫抑制作用与1毫克/千克/天的标准两性霉素B相似,但1毫克/千克/天的脂质体两性霉素B剂量在体内没有抑制作用。