二氯乙酰胺对硫代氨基甲酸酯类除草剂的解毒剂：作用模式。
Dichloroacetamide antidotes for thiocarbamate herbicides: mode of action.
作者信息
Lay M, Hubbell J P, Casida J E
出版信息
Science. 1975 Jul 25;189(4199):287-9. doi: 10.1126/science.1145201.
PMID:1145201
Abstract
Thiocarbamate sulfoxides formed on metabolic sulfoxidation of thicoarbamate herbicides in plants and mammals are effective carbamoylating agents for glutathione and other tissue thiols. Dichloracetamides that protect corn from thiocarbamate herbicide injury more rapid detoxification of the thiocarbamate sulfoxides by increasing their rate of carbamoylation of glutathione through elevation of the root glutathione level and glutathione s-transferase activity.
摘要
硫代氨基甲酸酯类除草剂在植物和哺乳动物体内经代谢硫氧化作用形成的硫代氨基甲酸酯亚砜，是谷胱甘肽和其他组织硫醇的有效氨甲酰化剂。二氯乙酰胺通过提高根部谷胱甘肽水平和谷胱甘肽S-转移酶活性，加快硫代氨基甲酸酯亚砜的氨甲酰化速率，从而更快速地使硫代氨基甲酸酯亚砜解毒，保护玉米免受硫代氨基甲酸酯类除草剂的伤害。
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