诺氏疟原虫疟疾的红细胞受体：达菲血型决定簇

Erythrocyte receptors for (Plasmodium knowlesi) malaria: Duffy blood group determinants.

作者信息

Miller L H, Mason S J, Dvorak J A, McGinniss M H, Rothman I K

出版信息

Science. 1975 Aug 15;189(4202):561-3. doi: 10.1126/science.1145213.

Abstract

Duffy blood group negative human erythrocytes (FyFy) are resistant to infection by Plasmodium knowlesi, a simian malaria that infects Duffy positive human erythrocytes. The P. knowlesi resistance factor, Duffy negative erythrocytes, occurs in high frequency in West Africa, where the people are resistant to vivax malaria. This suggests that Duffy blood group determinants (Fya or Fyb) may be erythrocyte receptors for P. vivax.

摘要

达菲血型阴性的人类红细胞（FyFy）对诺氏疟原虫感染具有抗性，诺氏疟原虫是一种感染达菲阳性人类红细胞的猿类疟疾。诺氏疟原虫的抗性因子，即达菲阴性红细胞，在西非人群中高频出现，那里的人对间日疟原虫具有抗性。这表明达菲血型决定簇（Fya或Fyb）可能是间日疟原虫的红细胞受体。