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冈比亚西部非洲人的达菲血型与疟疾流行情况

The Duffy blood group and malaria prevalence in Gambian West Africans.

作者信息

Welch S G, McGregor I A, Williams K

出版信息

Trans R Soc Trop Med Hyg. 1977;71(4):295-6. doi: 10.1016/0035-9203(77)90102-x.

DOI:10.1016/0035-9203(77)90102-x
PMID:339418
Abstract

Erythrocytes from 1,168 donors, comprising almost the entire populations of two rural Gambian villages, have been tested for Duffy blood group antigens using antisera to both Fya and Fyb. All tests were negative. Blood film examination of the same samples showed complete absence of Plasmodium vivax parasitaemia, but infections with P. falciparum,P. malariae and P. ovale were observed. The findings are consistent with the view that the Duffy-negative phenotype, FyFy, constitutes the basis of innate resistance towards infection with P. vivax but not towards infection with the other plasmodial species.

摘要

对来自1168名献血者的红细胞进行了检测,这些献血者几乎涵盖了冈比亚两个乡村的全部人口,使用抗Fya和Fyb血清检测达菲血型抗原。所有检测均为阴性。对相同样本进行血涂片检查显示完全没有间日疟原虫血症,但观察到有恶性疟原虫、三日疟原虫和卵形疟原虫感染。这些发现与以下观点一致,即达菲阴性表型FyFy构成了对间日疟原虫感染的先天抵抗力基础,但对其他疟原虫种类的感染则没有抵抗力。

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