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研究ACKR1与c-Myc在乳腺癌肿瘤微环境调节中的相互作用。

Investigating the interaction of ACKR1 and c-Myc in the breast carcinoma tumor microenvironment modulation.

作者信息

Talukdar Joyeeta, Nayek Arnab, Gogoi Gayatri, Srivastava Tryambak P, Goel Isha, Sahoo Om Saswat, Dhar Ruby, Karmakar Subhradip

机构信息

Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.

Department of Pathology, Assam Medical College, Dibrugarh, Assam, India.

出版信息

Discov Oncol. 2025 Aug 25;16(1):1615. doi: 10.1007/s12672-025-03437-8.

DOI:10.1007/s12672-025-03437-8
PMID:40853589
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12378275/
Abstract

This study investigates the interplay between the Atypical chemokine receptors (ACKR1)/Decoy receptor for chemokines (DARC) and key molecular markers, including CCL8, c-MYC, ALDH1, and CHEK2, in breast cancer. DARC has been implicated in various aspects of cancer progression, including tumor growth, angiogenesis, and metastasis. By analyzing the expression patterns of these markers in breast cancer tissues, we aim to understand their collective impact on tumor behaviour and identify potential therapeutic targets. Our findings reveal complex interactions between DARC and these molecular markers, suggesting their synergistic roles in promoting or repressing breast cancer progression. Understanding these relationships could lead to developing more effective and personalized therapeutic strategies.

摘要

本研究调查了非典型趋化因子受体（ACKR1）/趋化因子诱饵受体（DARC）与关键分子标志物（包括CCL8、c-MYC、ALDH1和CHEK2）在乳腺癌中的相互作用。DARC已被证明与癌症进展的各个方面有关，包括肿瘤生长、血管生成和转移。通过分析这些标志物在乳腺癌组织中的表达模式，我们旨在了解它们对肿瘤行为的综合影响，并确定潜在的治疗靶点。我们的研究结果揭示了DARC与这些分子标志物之间的复杂相互作用，表明它们在促进或抑制乳腺癌进展中具有协同作用。了解这些关系可能会导致开发出更有效和个性化的治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/6cdbce735533/12672_2025_3437_Fig11_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/6dadeab1242b/12672_2025_3437_Fig6a_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/835a68265c9c/12672_2025_3437_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/a99a9d33ee9d/12672_2025_3437_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/5a4f4950c8a4/12672_2025_3437_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7791/12378275/c424704c511b/12672_2025_3437_Fig10_HTML.jpg
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本文引用的文献

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The DARC side of genetics in cancer: Breast cancer disparities.遗传学中 DARC 基因的作用：乳腺癌的差异。
Am J Hum Genet. 2024 Jul 11;111(7):1261-1264. doi: 10.1016/j.ajhg.2024.05.011.
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50,000 years of Evolutionary History of India: Insights from ~2,700 Whole Genome Sequences.印度五万年的进化史：来自约2700个全基因组序列的见解
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Standardized pathology report for HER2 testing in compliance with 2023 ASCO/CAP updates and 2023 ESMO consensus statements on HER2-low breast cancer.
符合 2023 年 ASCO/CAP 更新和 2023 年 ESMO 关于 HER2 低乳腺癌共识声明的 HER2 检测标准化病理报告。
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Prospects for targeting ACKR1 in cancer and other diseases.靶向 ACKR1 在癌症和其他疾病中的应用前景。
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c-MYC mediates the crosstalk between breast cancer cells and tumor microenvironment.c-MYC 介导乳腺癌细胞与肿瘤微环境之间的串扰。
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