Meyle J, Gonzáles J R
Department of Periodontology, Zentrum für Zahn-, Mund und Kieferheilkunde, Universität Giessen, Giessen, Germany.
Periodontol 2000. 2001;26:92-112. doi: 10.1034/j.1600-0757.2001.2260105.x.
Systemic diseases affecting the host response as primary immunodeficiencies or secondary defects caused by lack of nutrients or changes in the local tissues are very often accompanied by early-onset prepubertal periodontitis. Local treatment in combination with systemic antibiotics may in milder forms improve the situation, but in many cases the success is questionable and premature loss of teeth occurs. Since the genetic basis of many of the diseases has been identified, future developments permit the correction of at least some of these defects by gene therapy.
作为原发性免疫缺陷或由营养缺乏或局部组织变化引起的继发性缺陷而影响宿主反应的全身性疾病，常常伴有青春期前早发性牙周炎。局部治疗联合全身用抗生素可能会在病情较轻的情况下改善状况，但在许多情况下，治疗效果存疑，且会过早出现牙齿脱落。由于许多此类疾病的遗传基础已被确定，未来的发展使得通过基因治疗至少纠正其中一些缺陷成为可能。
