Department of Paediatric Dentistry, Medical University of Warsaw, Binieckiego 6 Street, 02-097 Warsaw, Poland.
Int J Environ Res Public Health. 2022 Mar 13;19(6):3386. doi: 10.3390/ijerph19063386.
Premature loss of primary teeth can occur as a consequence of dental trauma, neonatal tooth extraction, early childhood caries, or periodontal problems, or it can be a manifestation of systemic disease. This review aims to present systemic disorders that can lead to premature loss of deciduous teeth in children and to provide a comprehensive resource for clinical practice for both physicians and dentists.
This study is a narrative review of original studies and case reports published in English and Polish between 1957 and 2021 that was conducted by searching electronic scientific resources: PubMed, Google Scholar, Web of Science, and Science Direct. The schema of the qualification process is represented by a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). In total, 196 articles were identified; after provisional assessment of the titles and abstracts by two reviewers, 46 were found to be relevant to the topic, including 1 review, 16 original papers, and 27 case reports regarding systemic disease resulting in premature tooth loss.
In this study, 16 systemic diseases were linked to premature primary tooth loss in children: Papillon-Lefèvre syndrome, mucocutaneous dyskeratosis, Coffin-Lowry syndrome, congenital adrenal hyperplasia, Langerhans cell histiocytosis, cherubism, hypophosphatasia, acatalasia, Chediak-Higashi syndrome, cyclic neutropenia, erythromelalgia, Down syndrome, Hajdu-Cheney syndrome, short bowel syndrome, leukocyte adhesion deficiency type 1 (LAD-1), and Wiedemann-Steiner syndrome (WSS).
乳恒牙过早丧失可由牙外伤、新生儿拔牙、幼儿龋、牙周问题引起，也可能是全身疾病的表现。本文旨在介绍可能导致儿童乳恒牙过早丧失的全身疾病，并为内科医生和牙医提供临床实践的综合资源。
本研究为 1957 年至 2021 年间发表的英文和波兰文原始研究和病例报告的叙述性综述，通过检索电子科学资源：PubMed、Google Scholar、Web of Science 和 Science Direct 进行。资格过程的方案由系统评价和荟萃分析的首选报告项目（PRISMA）表示。总共确定了 196 篇文章；经过两位评审员对标题和摘要的初步评估，发现 46 篇与主题相关，包括 1 篇综述、16 篇原始论文和 27 篇关于导致乳恒牙过早丧失的全身疾病的病例报告。
在这项研究中，有 16 种全身疾病与儿童乳恒牙过早丧失有关：掌跖角化过度症、黏膜皮肤角化不良、Coffin-Lowry 综合征、先天性肾上腺增生、朗格汉斯细胞组织细胞增生症、 cherubism、低磷酸酶血症、无酶血症、Chediak-Higashi 综合征、周期性中性粒细胞减少症、红血球增多性红热、唐氏综合征、Hajdu-Cheney 综合征、短肠综合征、白细胞黏附缺陷 1 型（LAD-1）和 Wiedemann-Steiner 综合征（WSS）。
