年轻人对脊髓灰质炎免疫力的下降。

Decline in immunity to polio among young adults.

作者信息

Grotto I, Handsher R, Gdalevich M, Mimouni D, Huerta M, Green M S, Mendelson E, Shpilberg O

机构信息

Israel Defence Forces, Medical Corps, 02149, Military Post, Israel.

出版信息

Vaccine. 2001 Jul 20;19(30):4162-6. doi: 10.1016/s0264-410x(01)00165-7.

DOI:10.1016/s0264-410x(01)00165-7

PMID:11457541

Abstract

A serologic survey was conducted on a population-based representative sample of 521 18-year-old soldiers recruited to the Israel Defence Forces in 1997. The prevalence of neutralizing antibodies and geometric mean titers (GMTs) against the three types of poliovirus (Mahoney, MEF and Saukett strains) were found to be 98.7% (GMT--169.95), 99.6% (GMT--297.14) and 96.4% (GMT - 59.48), respectively. These GMTs are markedly lower than those recorded 4 years after booster vaccination carried out during a 1988 polio outbreak, and suggest a decline in immunity against polio among young adults. These findings support the policy of routine revaccination of children and adolescents in countries at risk of imported polioviruses and of revaccination of adults traveling to areas to which polio is endemic.

摘要

对1997年招募进入以色列国防军的521名18岁士兵的具有人群代表性样本进行了血清学调查。发现针对三种脊髓灰质炎病毒（马奥尼、MEF和索基特毒株）的中和抗体流行率和几何平均滴度（GMT）分别为98.7%（GMT——169.95）、99.6%（GMT——297.14）和96.4%（GMT - 59.48）。这些GMT明显低于1988年脊髓灰质炎疫情期间进行加强免疫接种4年后记录的数值，表明年轻人对脊髓灰质炎的免疫力有所下降。这些发现支持在有输入脊髓灰质炎病毒风险的国家对儿童和青少年进行常规再接种以及对前往脊髓灰质炎流行地区的成年人进行再接种的政策。