Leaf A
Department of Medicine, Massachusetts General Hospital and the Harvard Medical School, Boston, MA, USA.
J Nutr Health Aging. 2001;5(3):173-8.
The purpose of this paper is to review the evidence that dietary factors, namely the ingestion of the n-3 (or w-3) polyunsaturated fatty acids of fish oils can prevent fatal cardiac arrhythmias (so-called sudden cardiac death) in experimental animals, and probably in humans as well. The mechanism for this striking effect results from the ability of these fatty acids to directly stabilize electrically every contractile myocyte in the heart. This is accomplished by modulation by the free n-3 fatty acids of the ionic currents in heart cells; particularly the voltage-dependent sodium currents which initiate action potentials and the L-type calcium currents, which initiate release of sarcoplasmic reticulum stores of calcium into the cytosol of heart cells. The resultant rise in cytosolic calcium concentration initiates contraction of the heart cells and the beating rate of the heart. The gradually accumulating clinical evidence that these fish oil fatty acids are potent preventors of cardiac sudden death in humans will be reviewed. With some 250,000 deaths occurring within one hour of the onset of acute myocardial infarctions annually in the USA alone and millions more in the whole world, the potential large public health benefit from this understanding is evident.
本文旨在综述相关证据，即饮食因素，也就是摄入鱼油中的n-3（或ω-3）多不饱和脂肪酸，可预防实验动物的致命性心律失常（即所谓的心源性猝死），在人类中可能也有此作用。这种显著效果的机制源于这些脂肪酸能够直接使心脏中的每个收缩性心肌细胞电稳定性增强。这是通过游离的n-3脂肪酸对心脏细胞离子电流的调节来实现的；特别是启动动作电位的电压依赖性钠电流以及启动肌浆网钙库向心脏细胞胞质溶胶释放钙的L型钙电流。由此导致的胞质钙浓度升高引发心脏细胞收缩和心脏跳动频率。将对这些鱼油脂肪酸是人类心源性猝死的有效预防剂这一逐渐积累的临床证据进行综述。仅在美国，每年就有大约25万人在急性心肌梗死发作后一小时内死亡，全球还有数百万例，因此从这一认识中潜在的巨大公共卫生益处显而易见。
