Leaf Alexander
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA.
J Cardiovasc Med (Hagerstown). 2007 Sep;8 Suppl 1:S27-9. doi: 10.2459/01.JCM.0000289270.98105.b3.
There were already several epidemiologic studies that showed eating fish frequently seemed to reduce deaths from coronary heart disease. There were also observational and clinical trials that more specifically showed that the reduction in cardiovascular deaths from eating fish was largely the result of the prevention of sudden cardiac death by n-3 polyunsaturated fatty acids in fish oil. This led me to perform a clinical trial in which all subjects had an implanted cardioverter-defibrillator and were at very high risk of sudden cardiac death. The results of this study and the mechanisms by which n-3 fish oil fatty acids prevent fatal cardiac arrhythmias will be the subject of this review.
已经有多项流行病学研究表明，经常吃鱼似乎能降低冠心病死亡率。也有观察性研究和临床试验更具体地表明，吃鱼导致心血管死亡人数减少，很大程度上是由于鱼油中的n-3多不饱和脂肪酸预防了心源性猝死。这促使我开展了一项临床试验，所有受试者都植入了心脏复律除颤器，且心源性猝死风险极高。本综述将探讨这项研究的结果以及n-3鱼油脂肪酸预防致命性心律失常的机制。
