来自头序虎尾兰根的抗疟和抗氧化异呋喃萘醌类化合物。

Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata.

作者信息

Bezabih M, Abegaz B M, Dufall K, Croft K, Skinner-Adams T, Davis T M

机构信息

Department of Chemistry, University of Botswana, Gaborone, Botswana.

出版信息

Planta Med. 2001 Jun;67(4):340-4. doi: 10.1055/s-2001-14329.

DOI:10.1055/s-2001-14329

PMID:11458451

Abstract

The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10'-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.

摘要

头状滨藜的根产生了新化合物5,8 - 二羟基 - 1 - 惕各酰甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮、1 - 乙酰氧基甲基 - 8 - 羟基萘并[2,3 - c]呋喃 - 4,9 - 二酮和1 - 乙酰氧基甲基 - 5,8 - 二羟基萘并[2,3 - c]呋喃 - 4,9 - 二酮，此外还含有已知化合物大黄酚、10,10'-大黄酚双蒽酮、8 - 羟基 - 1 - 甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮、5,8 - 二羟基 - 1 - 甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮、5,8 - 二羟基 - 1 - 羟甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮以及8 - 羟基 - 5 - 甲氧基 - 1 - 甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮或5 - 羟基 - 8 - 甲氧基 - 1 - 甲基萘并[2,3 - c]呋喃 - 4,9 - 二酮。这些新的以及已知的异呋喃萘醌显示出抗氧化和微弱的抗疟活性。